Symptoms of peritoneal mesothelioma Symptoms of peritoneal mesothelioma include: painful abdomen swollen abdomen high temperature nausea, vomiting and poor appetite bowel and urinary problems. Symptoms of mesothelioma in the advanced stages Symptoms in the later stages of the disease for both types include all those symptoms listed above, as well as: sudden and unexplained weight loss fatigue (both types) confusion due to chemical imbalances in the body or spread of the cancer to the brain. All symptoms discussed in this section can be caused by other, less serious diseases. However, if you or someone close to you has any of them (especially if you know you have been exposed to asbestos), you should see your doctor.